Air Freight Fundamentals

Temperature-Controlled / Cold Chain Air Freight Basics

Cold chain isn't just packing something cold — it's booking temperature-controlled handling directly with the carrier ahead of tender, since it isn't a walk-up acceptance.

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2–8°C

Standard pharma cold chain range

Active / Passive

Two broad cold chain equipment categories

CEIV Pharma

IATA's pharma cold chain quality certification

UN 1845

Dry ice DGR classification, where used

Active vs passive, and why the gaps matter most

Cold chain air freight broadly splits into active systems (powered temperature-controlled containers or ULDs maintaining a set range independent of ambient conditions) and passive systems (insulated packaging, gel packs, or dry ice relying on thermal mass rather than active power). The right choice depends on the product's sensitivity, transit duration, and the specific temperature excursions the route is likely to expose the shipment to.

The actual weak points in a cold chain are typically the handoffs, not the flight itself — ramp transfer time in ambient conditions, tarmac dwell during aircraft turnaround, and ground handling gaps before pickup at destination. A carrier's temperature-controlled handling commitment needs to cover these transition points specifically, not just the time cargo spends loaded on the aircraft.

IATA's CEIV Pharma certification is a voluntary quality standard for cold chain pharmaceutical handling that airports, ground handlers, and carriers can hold — its presence at a given hub is a real signal of cold chain infrastructure quality, though its absence doesn't automatically mean a shipment can't move safely, just that the specific handler's cold chain process hasn't been independently certified against that standard.

Booking Note

Temperature-controlled handling needs to be confirmed directly with the carrier ahead of tender — it isn't a walk-up acceptance

The carrier has to confirm equipment availability, ground handling capability at every transit point, and capacity for that specific flight before a cold chain shipment can be booked reliably. This needs meaningfully more lead time than standard general cargo — see our booking lead times guide.

General industry practice regarding cold chain air freight booking and handling. Source for the dry ice-specific rules: IATA Dangerous Goods Regulations, PI 954.

Worked example

A worked example: choosing between active and passive cold chain

Take a vaccine shipment (see our pharmaceuticals commodity page) needing a strict 2–8°C range across a multi-leg routing with a connection.

Given the connection and the resulting longer total transit time with a ground handling transfer in the middle, UAL confirms whether the carrier can commit to active temperature-controlled ULDs across both legs and the transfer point — a passive dry-ice or gel-pack solution sized only for a direct flight's duration risks running out of thermal buffer during an unplanned connection delay.

If dry ice is used as part of the cold chain solution, UN 1845 (Class 9) is declared on the AWB with vented packaging confirmed before acceptance, per IATA DGR PI 954's 200kg-per-package limit — covered in full on our dry ice shipping rules guide.

What UAL confirms before booking a cold chain shipment

We confirm the carrier's specific temperature-controlled handling capability across every leg and transfer point of the routing before booking, not just for the flight itself — and coordinate any required dry ice DGR declaration directly.

IATA DGR certified for dry ice declarations
Direct carrier coordination on active/passive cold chain equipment

Frequently asked questions

No — it depends on the specific temperature range needed and transit duration. Active powered containers don't require dry ice at all; passive solutions may or may not use it depending on the product's sensitivity and route length.

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Related

Source: IATA Dangerous Goods Regulations, PI 954 (dry ice); IATA CEIV Pharma certification program. Last verified July 2026.

Air Freight Fundamentals

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